López-Escobar, E. G. K. Introduction.--Kueker, D. W. Back-and-forth arguments and infinitary logics.--Green, J. Consistency properties for finite quantifier languages.--Cunningham, E. Chain models.--Gregory, J. On a finiteness condition for infinitary languages.

Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...) by several alleles (shared epitopes) are better descriptors of the actual causative genetic variants. Here we describe a novel approach to genetic association analysis in which genes/proteins are broken down into smaller sequence features and then variant types defined for each feature, allowing for independent analysis of disease association with each sequence feature variant type. We have used this approach to analyze a cohort of systemic sclerosis patients and show that a sequence feature composed of specific amino acid residues in peptide binding pockets 4 and 7 of HLA-DRB1 explains much of the molecular determinant of risk for systemic sclerosis. (shrink)

Résumé L’auteur fait ici partager plus de 30 ans d’expérience de l’étude du XVIIIe siècle dans les murs d’un institut académique russe. L’évolution de ses propres intérêts et des tendances historiographiques générales, la transformation du milieu académique, les changements dans l’organisation et le financement de la recherche russe sont placés dans le contexte plus large des métamorphoses dramatiques survenues dans son pays depuis la fin de l’ère soviétique jusqu’à nos jours.

D. D. Raphael examines the moral philosophy of Adam Smith (1723-90), best known for his famous work on economics, The Wealth of Nations, and shows that his thought still has much to offer philosophers today. Raphael gives particular attention to Smith's original theory of conscience, with its emphasis on the role of 'sympathy' (shared feelings).

1. Hobbes-Gay.--2. Hume-Bentham and Index.

In the myth of the Phaedrus Plato sets forth a picture of the life of discarnate souls in heaven. He represents these souls by the symbol of a winged charioteer driving winged horses. In the case of the souls of the gods, the charioteers and horses are good. In the case of the other souls whom Plato calls daimones, and among whom our own souls are included, the soul is represented by a charioteer with two horses of which the right (...) one is good but the left one evil. It is generally agreed that the right and left horses represent thumos and passion respectively, while the charioteer symbolizes reason. Plato goes on to describe a procession which the gods and daimones make up to the outer edge of heaven in order to contemplate the Forms which lie beyond. The gods, we are told, make the ascent easily and when they reach the edge of heaven have no difficulty in staying there and beholding the Forms. The daimones, however, experience difficulty due to the recalcitrance of the evil horse, which all their charioteers possess (247 b Plato divides the daimones into three main groups: those who succeed in beholding the Forms though with difficulty; those whose vision is only partial; those, finally, who fail to see the Forms at all. Since contemplation of the Forms provides the nourishment by which the wings of the soul are nurtured, those daimones who fail to see the Forms at all lose their wings and fall to earth. They have to go through a series of earthly existences for 10,000 years, before they regain their wings and return to heaven. (shrink)

D. D. Raphael; VI*—Hume and Adam Smith on Justice and Utility, Proceedings of the Aristotelian Society, Volume 73, Issue 1, 1 June 1973, Pages 87–104, https://d.

What darkness was the ‘Enlightenment’ supposed to have removed? The answer is irrational forms of religion. Most of the ‘enlightened’ took the view that revealed religion was irrational and that natural religion could be rational; but some were sceptical about natural religion too. Hume was the most honest and the most penetrating thinker of the latter group. His biographer, Professor E. C. Mossner, is not alone in believing that the Dialogues concerning Natural Religion is ‘his philosophical testament’.

What darkness was the ‘Enlightenment’ supposed to have removed? The answer is irrational forms of religion. Most of the ‘enlightened’ took the view that revealed religion was irrational and that natural religion could be rational; but some were sceptical about natural religion too. Hume was the most honest and the most penetrating thinker of the latter group. His biographer, Professor E. C. Mossner, is not alone in believing that the Dialogues concerning Natural Religion is ‘his philosophical testament’.

Professor Maurice Cranston, who died suddenly on 5 November 1993, was a man of many talents. Pre-eminent as a biographer of Locke and Rousseau, he was also distinguished for his own contribution to political philosophy and for his capacity to expound the political thought of others in clear, simple language. He did this with great success not only in the lecture room but also in numerous broadcast talks and discussions, notably on the Third Programme of the BBC. In his academic (...) work he was particularly well informed on French political thought, contemporary as much as classical, and he wrote extensively on Sartre and more briefly on Camus and Foucault. He was himself fluent in the French language and he translated Rousseau's Social Contract and Discourse on Inequality for the Penguin Classics series. He was proficient in German and Italian too, and he knew enough Danish to translate a book on Wittgenstein written in that language. His love of literature often led him to illustrate philosophical points with apt examples from classical novels. He even wrote a couple of novels himself in his youth. It will be plain from this brief catalogue that he was an eminently civilized person. He was, in addition, an exceptionally friendly man and engagingly modest about his own abilities. (shrink)

D. D. Raphael; I—The Presidential Address*: The Standard of Morals, Proceedings of the Aristotelian Society, Volume 75, Issue 1, 1 June 1975, Pages 1–12E, https.

A scholarly edition of a work by Adam Smith. The edition presents an authoritative text, together with an introduction, commentary notes, and scholarly apparatus.

In the introductory chapter of his essay on Utilitarianism, John Stuart Mill says his aim is to contribute towards the understanding of utilitarianism and towards ‘such proof as it is susceptible of’. He immediately adds that ‘this cannot be proof in the ordinary and popular meaning of the term’ because ‘ultimate ends are not amenable to direct proof’. A proof that something is good has to show that it is ‘a means to something admitted to be good without proof’. But, (...) he goes on, this does not imply that a formula of ultimate ends can only be accepted on ‘blind impulse, or arbitrary choice’. It can be rationally discussed and subjected to proof in a wider sense of that word. ‘Considerations may be presented capable of determining the intellect either to give or withhold its assent to the doctrine; and this is equivalent to proof.’. (shrink)

Book reviewed in this article:F.H. Bradley, Collected Works Volumes 1–5.

The enigmatic genius of great mathematician and historian DD Kosambi shines through this book comprising his four essays, two of which, discovered in his papers, are being published for the first time. The book sheds a new light on his personality and range of his interests and concerns. Meticulously researched edited by Ram Ramaswamy this little book will be of great interest to all students of science and intellectual history.